Clinical Evidence & Ingredient Research

Multiple ingredients in our formulas are supported by peer-reviewed studies showing improvements in elasticity, firmness, skin hydration, barrier function, and fine lines — all key concerns in crepey, thinning skin.

Every study below is linked to its PubMed record so you can read it yourself.

Niacinamide (Vitamin B3)

Studied for its effects on elasticity, smoothness, fine lines, and barrier strength.

Study 1: Improved elasticity & fine lines
Study 2: Ceramides & barrier function
Study 3: Reduces hyperpigmentation & roughness
Study 4: Anti-aging benefits in photoaged skin

Bakuchiol (Retinol-like alternative)

Studied for its effects on wrinkles and pigmentation with better tolerability than retinol.

Study 1: Wrinkle appearance vs retinol
Study 2: Anti-aging & antioxidant effects
Study 3: Skin firmness & wrinkle depth

Palmitoyl Tripeptide-5

Peptide studied for its effects on skin firmness and wrinkle appearance.

Study 1: Skin firmness & wrinkle appearance
Study 2: Improved firmness and dermal density
Study 3: In vivo wrinkle depth improvement

Ceramides (NP, AP, EOP) + Cholesterol + Phytosphingosine

Studied for their effects on barrier function, elasticity and hydration in aging skin.

Study 1: Barrier function with ceramide-cholesterol
Study 2: Barrier improvement in mature skin
Study 3: Improved hydration & elasticity
Study 4: Aging skin benefits from ceramide supplementation

Urea

Studied for its effects on skin smoothness, moisture retention and texture.

Study 1: Hydration & barrier function
Study 2: Reduces roughness in dry, aged skin
Study 3: Elasticity & softness

Sodium Hyaluronate (Hyaluronic Acid)

Studied for its effects on hydration, firmness, and the appearance of fine lines.

Study 1: Reduced wrinkles & improved hydration
Study 2: Elasticity & firmness improvements
Study 3: Skin plumping & wrinkle appearance

Centella Asiatica

Studied for its effects on skin firmness and signs of aging.

Study 1: Skin firmness improvement
Study 2: Anti-aging & wrinkle appearance
Study 3: Elasticity improvement in photoaged skin

Green Tea (Camellia Sinensis)

Studied for its antioxidant effects on skin texture, elasticity and aging.

Study 1: Improved elasticity & roughness
Study 2: Anti-aging & anti-inflammatory effects
Study 3: Benefits for photodamaged skin

Aloe Vera

Studied for its effects on hydration, smoothness and skin firmness.

Study 1: Skin firmness & wrinkle appearance
Study 2: Elasticity & hydration improvements
Study 3: Skin texture improvements

These statements have not been evaluated by the Food and Drug Administration. Dermea products are cosmetics and are not intended to diagnose, treat, cure or prevent any disease. The research linked above concerns the individual ingredients, not finished Dermea products. Individual results vary.